{"id":2520,"date":"2022-09-28T11:28:40","date_gmt":"2022-09-28T10:28:40","guid":{"rendered":"https:\/\/springerhealthcare.nl\/france\/?p=2520"},"modified":"2023-01-24T15:58:10","modified_gmt":"2023-01-24T15:58:10","slug":"china-and-india-approve-nasal-covid-vaccines-are-they-a-game-changer","status":"publish","type":"post","link":"https:\/\/springerhealthplus.nl\/shmigrate\/china-and-india-approve-nasal-covid-vaccines-are-they-a-game-changer\/","title":{"rendered":"China and India approve nasal COVID vaccines \u2014 are they a game changer?"},"content":{"rendered":"

[vc_row full_width=”stretch_row” content_placement=”middle” css=”.vc_custom_1663187695627{padding-bottom: 37px !important;background-image: url(http:\/\/springerhealthcare.nl\/wp-content\/uploads\/sites\/24\/2022\/09\/science_connect_back.png?id=2486) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” el_class=”sciencetitle”][vc_column][vc_custom_heading text=”Science Connect” font_container=”tag:h2|text_align:left|color:%23ffffff” use_theme_fonts=”yes” link=”url:https%3A%2F%2Fspringerhealthcare.nl%2Ffrance%2Fscience-connect-november-2022%2F”][vc_column_text css=”.vc_custom_1663186747780{margin-bottom: 40px !important;}”]A Springer Healthcare Initiative For Pharma Professionals<\/span>[\/vc_column_text][vc_column_text]JANUARY 2023
\n<\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1538651642953{padding-top: 75px !important;}”][vc_column width=”3\/4″ css=”.vc_custom_1538657061395{border-right-width: 1px !important;padding-top: 0px !important;border-right-color: #8faec1 !important;border-right-style: solid !important;}”][vc_custom_heading source=”post_title” font_container=”tag:h1|font_size:40px|text_align:left|line_height:60px” google_fonts=”font_family:Merriweather%3Aregular%2Citalic|font_style:700%20regular%3A700%3Anormal” el_class=”title” css=”.vc_custom_1664358136969{margin-bottom: 30px !important;}”][vc_column_text el_class=”intro-box”]Scientists hope the immunizations, delivered through the nose or mouth, will prevent even mild cases of illness.<\/strong><\/span><\/p>\n

Emily Waltz<\/span>[\/vc_column_text][vc_single_image source=”featured_image” img_size=”full” alignment=”center” css=”.vc_custom_1667916355202{margin-bottom: 0px !important;}” el_class=”hero-img”][vc_column_text css=”.vc_custom_1667916369719{margin-bottom: 30px !important;}”]CanSino Biologics\u2019 inhaled vaccine has the same ingredients as the company\u2019s COVID-19 shot that is already available in China.<\/span>Credit: Chen Yuancai\/VCG\/Getty<\/span>[\/vc_column_text][vc_column_text]<\/p>\n

\n

Two needle-free COVID-19 vaccines that are delivered through the nose or mouth have been approved for use in China and India. China\u2019s new vaccine, announced on Sunday, is inhaled through the nose and mouth as an aerosolized mist, and India\u2019s, announced on Tuesday, is administered as drops in the nose.<\/p>\n

These mucosal vaccines target thin mucous membranes that line the nose, mouth and lungs. By prompting immune responses where SARS-CoV-2 first enters the body, mucosal vaccines could, in theory, prevent even mild cases of illness and block transmission to other people \u2014 something COVID-19 shots have been unable to do. Vaccines that produce sterilizing immunity would be game changing for the pandemic.<\/p>\n

\u201cThese approvals validate the need for mucosal vaccines,\u201d says Marty Moore, co-founder of Meissa Vaccines in Redwood City, California, which is developing a COVID-19 immunization that is delivered through the nose. \u201cThat\u2019s the direction we need to go globally, and the United States needs to catch up.\u201d<\/p>\n

The regulatory nods from China and India bring the number of approved COVID-19 mucosal vaccines in the world to four, including one already approved in Iran and another in Russia. More than 100 mucosal vaccines against the disease are in development globally, and about 20 have reached clinical trials in humans, according to Airfinity, a health-analytics company in London. Delivery methods include sprays, drops, aerosols and pills.<\/p>\n

New arrivals<\/h2>\n

China\u2019s inhaled vaccine, developed by CanSino Biologics in Tianjin, contains the same ingredients as the company\u2019s COVID-19 shot that is already available in the country. A device called a nebulizer turns the liquid vaccine into an aerosol spray that is inhaled. China\u2019s health department and National Medical Products Administration approved the vaccine to be used as a booster dose.<\/p>\n

India\u2019s vaccine, developed by Bharat Biotech in Hyderabad, is approved as a two-dose primary inoculation, rather than a booster.<\/p>\n

Both companies have produced \u2018viral vector\u2019 vaccines that use a harmless adenovirus to deliver SARS-CoV-2 genetic material into host cells. Neither company has published phase III clinical-trial data, but both say they have completed those studies.<\/p>\n

Data from a phase II trial of CanSino\u2019s inhaled vaccine found that, when given as a booster, the vaccine raised blood-serum antibody levels significantly more than did a boost from an injection. This suggests that the inhaled vaccine will offer protection that is as good as, or better than, that provided by the shot.<\/p>\n

Similarly, Bharat compared its intranasal vaccine to Covaxin, a COVID-19 jab available in India, by measuring antibody levels in the blood. The company did not release results of this study, but deemed the trial \u201csuccessful\u201d.<\/p>\n

Exactly how successful these vaccines will be is unclear. Expecting a vaccine to stop transmission of a virus or prevent even mild illness \u2014 achieving what is called sterilizing immunity \u2014 is a high bar. Bharat and CanSino won\u2019t know whether their vaccines can achieve this until they have conducted further efficacy studies.<\/p>\n

Scant data are available on the efficacy of the two other mucosal COVID-19 vaccines. Iran approved a COVID-19 vaccine administered as a nasal spray and made by Razi Vaccine and Serum Research Institute in Karaj in October 2021. More than 5,000 doses have been delivered to the public. And Russia\u2019s health ministry is reported to have approved an intranasal-spray version of Sputnik V, the country\u2019s injected COVID-19 vaccine.<\/p>\n

Mucosal vaccines have been developed for other diseases, including polio, influenza and cholera. Most of these vaccines are taken orally, and one, against flu, is administered through the nose.<\/p><\/div>\n

Nature<\/em>\u00a0609<\/strong>, 450 (2022)<\/p>\n

doi: https:\/\/doi.org\/10.1038\/d41586-022-02851-0<\/em><\/p>\n

\u00a9 2022 Springer Nature Limited. All rights reserved.[\/vc_column_text][\/vc_column][vc_column width=”1\/4″ css=”.vc_custom_1538657003956{padding-top: 0px !important;padding-bottom: 0px !important;}”][vc_custom_heading text=”ISSUES” font_container=”tag:h3|font_size:12px|text_align:left|color:%23333333|line_height:18px” use_theme_fonts=”yes” el_class=”titlewidget”][vc_column_text el_class=”columnflex” css=”.vc_custom_1664403812178{margin-bottom: 40px !important;}”]

October 2023<\/a><\/p>\r\n

September 2023<\/a><\/p>\r\n

August 2023<\/a><\/p>[\/vc_column_text][vc_custom_heading text=”OTHER ARTICLES IN THIS ISSUE” font_container=”tag:h3|font_size:12px|text_align:left|color:%23333333|line_height:18px” use_theme_fonts=”yes” el_class=”titlewidget” css=”.vc_custom_1667916421301{margin-bottom: 15px !important;}”][vc_basic_grid post_type=”post” max_items=”3″ element_width=”12″ orderby=”rand” item=”538″ grid_id=”vc_gid:1674575877623-ec58c570-e063-2″ taxonomies=”24″][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"Scientists hope the immunizations, delivered through the nose or mouth, will prevent even mild cases of illness. ...more<\/a>","protected":false},"author":29,"featured_media":2521,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[7],"tags":[24],"class_list":{"0":"post-2520","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-science-connect","8":"tag-january-2023"},"acf":[],"yoast_head":"\nChina and India approve nasal COVID vaccines \u2014 are they a game changer? 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